Congenital Leigh's disease: Panencephalomyelopathy and peripheral neuropathy

@article{Seitz1984CongenitalLD,
  title={Congenital Leigh's disease: Panencephalomyelopathy and peripheral neuropathy},
  author={R{\"u}diger J. Seitz and Klaus Langes and Hartmut Frenzel and Georg Kluitmann and Wolfgang Wechsler},
  journal={Acta Neuropathologica},
  year={1984},
  volume={64},
  pages={167-171}
}
A dystrophic newborn girl (38th week of gestation) presented as a floppy infant with relapsing episodes of lactic acidosis and progressive cerebral deterioration. She died after serious apnoea at the age of 8 weeks. Neuropathological examination demonstrated widespread changes of Leigh's subacute polioencephalomyelopathy affecting the cerebral cortex, basal ganglia, mesencephalon and spinal cord. In addition, there was severe leukoencephalopathy of the cerebral hemispheres with sudanophilic… CONTINUE READING
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