Congenital Intestinal Aganglionosis in White Foals
@article{Vonderfecht1983CongenitalIA, title={Congenital Intestinal Aganglionosis in White Foals}, author={Steven L. Vonderfecht and Ann T. Bowling and M. Cohen}, journal={Veterinary Pathology}, year={1983}, volume={20}, pages={65 - 70} }
A congenital and probably hereditary neurological defect has been identified in the intestinal tract of six foals produced from the breeding of overo (a type of spotting pattern) horses. The foals had white hair and pink skin with the exception of occasional pigmented foci about the muzzle, ventral abdomen, and hindquarters. The foals appeared normal at birth, but within a few hours developed symptoms of colic. At necropsy, the only significant finding was a narrow, pale segment of large…
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References
SHOWING 1-10 OF 20 REFERENCES
Ileocolonic aganglionosis in white progeny of overo spotted horses.
- Medicine
- 1982
The congenital absence of myenteric ganglia in the terminal portion of the ileum, cecum, and entire colon of white foals with overo spotted parents was reported. Males as well as females were…
Total colonic aganglionosis.
- MedicineCanadian journal of surgery. Journal canadien de chirurgie
- 1978
Of the various procedures utilized, the Lester Martin operation has proved to be the most satisfactory, although determination of cholinesterase activity in the biopsy specimen and in the patient's serum was of some value.
Total colonic aganglionosis.
- Medicine
- 1978
Of the various procedures utilized, the Lester Martin operation has proved to be the most satisfactory, although determination of cholinesterase activity in the biopsy specimen and in the patient's serum was of some value.
Hirschsprung's disease: its aetiology, pathogenesis and differential diagnosis.
- MedicineCurrent topics in pathology. Ergebnisse der Pathologie
- 1974
Dalla-Valle was the first to point out, in papers published in 1920 and 1924, that Hirschsprung’s disease resulted from absence from the distal colon of the myenteric plexus, and Alvarez (1922) showed that the spastic segment of the supra-anal colon was the cause of Hirsch Springer's disease.
Hirschsprung's disease: absence of serotonergic neurons in the aganglionic colon.
- Medicine, BiologyJournal of pediatric surgery
- 1978
Autonomic nerves in rectum and colon in Hirschsprung's disease. A cholinesterase and catecholamine histochemical study.
- MedicineArchives of disease in childhood
- 1969
The autonomic nervous system innervates normal bowel in a complicated manner. Study of these nerves has been facilitated by histochemical techniques which enable separate identification of…
The migration of neural crest cells to the wall of the digestive tract in avian embryo.
- BiologyJournal of embryology and experimental morphology
- 1973
It is demonstrated by this technique that the parasympathetic enteric ganglion cells arise from two different levels of the embryonic neural axis which correspond to the vagal and lumbo-sacral parASYmpathetic centres.
AN EXPERIMENTAL INVESTIGATION OF PATTERN DEVELOPMENT IN LETHAL SPOTTING AND BELTED MOUSE EMBRYOS.
- BiologyDevelopmental biology
- 1964