Congenital Intestinal Aganglionosis in White Foals

@article{Vonderfecht1983CongenitalIA,
  title={Congenital Intestinal Aganglionosis in White Foals},
  author={Steven L. Vonderfecht and Ann T. Bowling and M. Cohen},
  journal={Veterinary Pathology},
  year={1983},
  volume={20},
  pages={65 - 70}
}
A congenital and probably hereditary neurological defect has been identified in the intestinal tract of six foals produced from the breeding of overo (a type of spotting pattern) horses. The foals had white hair and pink skin with the exception of occasional pigmented foci about the muzzle, ventral abdomen, and hindquarters. The foals appeared normal at birth, but within a few hours developed symptoms of colic. At necropsy, the only significant finding was a narrow, pale segment of large… Expand
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33 Citations

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Citation Type

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This is to the authors' knowledge the first description of an ENDRB gene deletion and associated clinical signs in a mammalian species different from humans and rodents. Expand
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Most defective neonates go unrecorded and unnoticed by veterinarians, animal scientists, and geneticists, so under unusual circumstances, when the defect occurs repeatedly in the same herd, flock, family, or geographic area, is a defective neonate likely to come to the attention of investigators concerned with congenital defects. Expand
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TLDR
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References

SHOWING 1-10 OF 20 REFERENCES
Ileocolonic aganglionosis in white progeny of overo spotted horses.
The congenital absence of myenteric ganglia in the terminal portion of the ileum, cecum, and entire colon of white foals with overo spotted parents was reported. Males as well as females were… Expand
Total colonic aganglionosis.
  • J. Louw
  • Medicine
  • Canadian journal of surgery. Journal canadien de chirurgie
  • 1978
TLDR
Of the various procedures utilized, the Lester Martin operation has proved to be the most satisfactory, although determination of cholinesterase activity in the biopsy specimen and in the patient's serum was of some value. Expand
Total colonic aganglionosis.
TLDR
Of the various procedures utilized, the Lester Martin operation has proved to be the most satisfactory, although determination of cholinesterase activity in the biopsy specimen and in the patient's serum was of some value. Expand
Hirschsprung's disease: its aetiology, pathogenesis and differential diagnosis.
  • W. Meier-Ruge
  • Medicine
  • Current topics in pathology. Ergebnisse der Pathologie
  • 1974
TLDR
Dalla-Valle was the first to point out, in papers published in 1920 and 1924, that Hirschsprung’s disease resulted from absence from the distal colon of the myenteric plexus, and Alvarez (1922) showed that the spastic segment of the supra-anal colon was the cause of Hirsch Springer's disease. Expand
Hirschsprung's disease: a review of the morphology and physiology.
  • E. Howard
  • Medicine
  • Postgraduate medical journal
  • 1972
MANY theories have been postulated to account for 'congenital megacolon' since the classical description by Hirschsprung in 1888. At first the dilated bowel of the megacolon attracted most of the… Expand
Lethal white foals in matings of overo spotted horses
TLDR
Data is presented which shows that neonatal isoerythrolysis (NI) is not involved in the death of the white foals, and further research is needed to define the nature of the lethal anomaly, as well as the genetics, of overo and lethal white foal. Expand
Hirschsprung's disease: absence of serotonergic neurons in the aganglionic colon.
TLDR
The results suggest that 5-HT-containing neurons are present in the normal human intestine and that these neurons are absent in the aganglionic segment in Hirshsprung's disease. Expand
Autonomic nerves in rectum and colon in Hirschsprung's disease. A cholinesterase and catecholamine histochemical study.
The autonomic nervous system innervates normal bowel in a complicated manner. Study of these nerves has been facilitated by histochemical techniques which enable separate identification of… Expand
The migration of neural crest cells to the wall of the digestive tract in avian embryo.
TLDR
It is demonstrated by this technique that the parasympathetic enteric ganglion cells arise from two different levels of the embryonic neural axis which correspond to the vagal and lumbo-sacral parASYmpathetic centres. Expand
AN EXPERIMENTAL INVESTIGATION OF PATTERN DEVELOPMENT IN LETHAL SPOTTING AND BELTED MOUSE EMBRYOS.
TLDR
The results of the grafting series clearly indicate that melanoblasts migrate freely throughout all areas of the skin of belted mice and that the genetic block is at the level of the hair follicle, substantiate the view that bt acts specifically on thehair follicle. Expand
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