Congenital Heart Block in Newborns of Mothers with Connective Tissue Disease

@article{Mccue1977CongenitalHB,
  title={Congenital Heart Block in Newborns of Mothers with Connective Tissue Disease},
  author={Carolyn M Mccue and M E Mantakas and Jon B. Tingelstad and Shaun Ruddy},
  journal={Circulation},
  year={1977},
  volume={56},
  pages={82–90}
}
Of 22 children with congenital complete heart block (CCHB) available for study, 14 (63.6%percnt;) were born to 11 mothers with clinical or laboratory evidence of connective tissue disease, primarily lupus erythematosus (LE). Seven mothers had both clinical and laboratory evidence of disease while four had only positive laboratory studies including fluorescent antinuclear antibody, rheumatoid factor, and depressed complement levels. In adults with systemic LE, pathologic changes in the collagen… 
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288 Citations
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288 Citations

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Citation Type

Congenital heart block and cardiac anomalies in the absence of maternal connective tissue disease.
Congenital complete heart block in the newborn associated with maternal systemic lupus erythematosus and other connective tissue disorders.
TLDR
It is concluded that congenital heart block is more common than had previously been appreciated.
Autoantibody-associated congenital heart block: The clinical perspective
TLDR
Congenital heart block and other abnormalities affecting the skin, liver, and blood elements were associated with anti-Ro/La antibodies in the maternal and fetal circulation, and are now grouped under the heading of neonatal lupus syndromes.
Congenital complete heart block and SSA antibodies: obstetric implications.
Complete congenital heart block in autoimmune hepatitis (SLA-positive).
Maternal connective tissue disease and congenital heart block. Demonstration of immunoglobulin in cardiac tissue.
TLDR
A report described antibodies to a soluble tissue ribonucleoprotein antigen called Ro(SS-A) in the serum of 34 of 41 mothers who had given birth to infants with congenital complete heart block, suggesting that maternal antibody to Ro(A) might serve as a marker to identify women at risk of having an infant.
Autoimmune-Associated Congenital Heart Block
TLDR
The identification of conduction abnormalities and subsequent detection of maternal autoantibodies to SSA/Ro and SSB/La ribonucleoproteins is approaching the predictable, even in mothers who are completely asymptomatic.
Autoantibody-Associated Congenital Heart Block: Outcome in Mothers and Children
TLDR
The laboratory evaluated the sera of 60 mothers whose children had congenital heart block and 5 women currently carrying fetuses with heart block to address the long-term outcome of these mothers and their children and evaluated whether maternal autoantibodies to the 52-kd SSA/Ro, 60-kD SSA-Ro, or 48-k d SSB/La proteins were associated with the clinical prognosis of the mother or her child.
Congenital complete heart block and connective-tissue disease.
TLDR
A cooperative study of 599 infants and children with congenital complete heart block found an association with systemic lupus erythematosus, but the cause was obscure and speculations included tumors, fetal endocarditis, endocardial fibroelastosis, interstitial myocarditis and genetic influences.
The clinical spectrum of autoimmune congenital heart block
TLDR
The epidemiology, classification and management of women whose pregnancies are affected by autoimmune CHB are discussed, with a particular focus on the autoantibodies associated with autoimmuneCHB and how to test for these antibodies and diagnose this disease.
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References

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