Congenital Adrenal Hyperplasia: Time to Replace 17OHP with 21-Deoxycortisol

@article{Miller2019CongenitalAH,
  title={Congenital Adrenal Hyperplasia: Time to Replace 17OHP with 21-Deoxycortisol},
  author={Walter L. Miller},
  journal={Hormone Research in Paediatrics},
  year={2019},
  volume={91},
  pages={416 - 420}
}
  • W. Miller
  • Published 26 August 2019
  • Medicine, Biology
  • Hormone Research in Paediatrics
Congenital adrenal hyperplasia (CAH) due to steroid 21-hydroxylase deficiency (21OHD) has a worldwide incidence of 1 in 15–20,000. Affected individuals have adrenal insufficiency and androgen excess; the androgen excess begins during fetal life, typically resulting in 46,XX disordered sexual development. In 21OHD, 17-hydroxyprogesterone (17OHP), the steroid proximal to 21-hydroxylase, accumulates. Most industrialized countries have newborn screening programs that measure 17OHP; such screening… 

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