Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation

  title={Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation},
  author={S. Hammad and Amnah Othman and C. Meyer and A. Telfah and J. Lambert and B. Dewidar and J. Werle and Z. C. Nwosu and A. Mahli and C. Dormann and Y. Gao and K. Gould and Mei Han and X. Yuan and Mikheil Gogiashvili and R. Hergenr{\"o}der and C. Hellerbrand and Maria Thomas and M. Ebert and S. Amasheh and J. Hengstler and S. Dooley},
  journal={Archives of Toxicology},
Tamoxifen (TAM) is commonly used for cell type specific Cre recombinase-induced gene inactivation and in cell fate tracing studies. Inducing a gene knockout by TAM and using non-TAM exposed mice as controls lead to a situation where differences are interpreted as consequences of the gene knockout but in reality result from TAM-induced changes in hepatic metabolism. The degree to which TAM may compromise the interpretation of animal experiments with inducible gene expression still has to be… Expand
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