Confounding factors in diagnostics of MGMT promoter methylation status in glioblastomas in stereotactic biopsies.

@article{Weise2014ConfoundingFI,
  title={Confounding factors in diagnostics of MGMT promoter methylation status in glioblastomas in stereotactic biopsies.},
  author={Lutz Martin Weise and Patrick N Harter and Sebastian Eibach and Anne K Braczynski and Maika Dunst and Johannes Rieger and Oliver B{\"a}hr and Elke Hattingen and Joachim Peter Steinbach and Karl Heinz Plate and V. Seifert and Michel Mittelbronn},
  journal={Stereotactic and functional neurosurgery},
  year={2014},
  volume={92 3},
  pages={129-39}
}
BACKGROUND In nonresectable glioblastoma (GBM), stereotactic biopsies are performed to retrieve tissue for diagnostic purposes. The analysis of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation adds prognostic and predictive information. OBJECTIVES The aim of the study was to detect confounding factors that limit the number of conclusive MGMT promoter methylation results. METHODS We analyzed 71 consecutive GBM patients undergoing stereotactic biopsy on whom MGMT analysis… CONTINUE READING
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