Confounding and heterogeneity in genetic association studies with admixed populations.

  title={Confounding and heterogeneity in genetic association studies with admixed populations.},
  author={Jinghua Liu and Juan Pablo Lewinger and Frank D Gilliland and William James Gauderman and David V. Conti},
  journal={American journal of epidemiology},
  volume={177 4},
Association studies among admixed populations pose many challenges including confounding of genetic effects due to population substructure and heterogeneity due to different patterns of linkage disequilibrium (LD). We use simulations to investigate controlling for confounding by indicators of global ancestry and the impact of including a covariate for local ancestry. In addition, we investigate the use of an interaction term between a single-nucleotide polymorphism (SNP) and local ancestry to… CONTINUE READING
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