Confounded cytosine! Tinkering and the evolution of DNA

  title={Confounded cytosine! Tinkering and the evolution of DNA},
  author={Anthony M. Poole and D. Penny and Britt-Marie Drottz Sj{\"o}berg},
  journal={Nature Reviews Molecular Cell Biology},
Early in the history of DNA, thymine replaced uracil, thus solving a short-term problem for storing genetic information — mutation of cytosine to uracil through deamination. Any engineer would have replaced cytosine, but evolution is a tinkerer not an engineer. By keeping cytosine and replacing uracil the problem was never eliminated, returning once again with the advent of DNA methylation. 
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