Conformer populations of L-iduronic acid residues in glycosaminoglycan sequences.

@article{Ferro1990ConformerPO,
  title={Conformer populations of L-iduronic acid residues in glycosaminoglycan sequences.},
  author={Dino R. Ferro and Augusto Provasoli and Massimo Ragazzi and Benito Casu and Giangiacomo Torri and V Bossennec and Bruno Perly and Pierre Sina{\"y} and Maurice Petitou and J P Choay},
  journal={Carbohydrate research},
  year={1990},
  volume={195 2},
  pages={157-67}
}
The 1H-n.m.r. 3J values for the L-iduronic acid (IdoA) residues for solutions in D2O of natural and synthetic oligosaccharides that represent the biologically important sequences of dermatan sulfate, heparan sulfate, and heparin have been rationalized by force-field calculations. The relative proportions of the low-energy conformers 1C4, 2S0, and 4C1 vary widely as a function of sequence and of pattern of sulfation. When IdoA or IdoA-2-sulfate units are present inside saccharide sequences, only… CONTINUE READING