Conformations of the regulatory domain of cardiac troponin C examined by residual dipolar couplings.

@article{Pkknen2000ConformationsOT,
  title={Conformations of the regulatory domain of cardiac troponin C examined by residual dipolar couplings.},
  author={Kati P{\"a}{\"a}kk{\"o}nen and Tia Sorsa and Torbj{\"o}rn Drakenberg and Piero Pollesello and Carola Tilgmann and Perttu Permi and Sami Heikkinen and Ilkka Kilpel{\"a}inen and Arto Annila},
  journal={European journal of biochemistry},
  year={2000},
  volume={267 22},
  pages={6665-72}
}
Conformations of the regulatory domain of cardiac troponin C (cNTnC) were studied by means of residual dipolar couplings measured from samples dissolved in dilute liquid crystals. Changes in the main chain HN residual dipolar couplings revealed a conformational change in cNTnC due to the complexation with the second binding region (amino acids 148-163) of cardiac troponin I (cTnI). Formation of the complex is accompanied with a molecular realignment in the liquid crystal. The residual dipolar… CONTINUE READING