Conformations of synthetic beta peptides in solid state and in aqueous solution: relation to toxicity in PC12 cells.

@article{Buchet1996ConformationsOS,
  title={Conformations of synthetic beta peptides in solid state and in aqueous solution: relation to toxicity in PC12 cells.},
  author={Ren{\'e} Buchet and E. Tavitian and Dorothee Ristig and Rolf Swoboda and U Stauss and H U Gremlich and L de la Fourni{\`e}re and Matthias Staufenbiel and Peter Frey and David A. Lowe},
  journal={Biochimica et biophysica acta},
  year={1996},
  volume={1315 1},
  pages={40-6}
}
The secondary structures of peptides beta 25-35 (the active toxic fragment) and beta 35-25 (reverse sequence and non-toxic fragment), as well as of the amidated beta (25-35)-NH2 peptide were investigated in aqueous solution and in the solid state by means of Fourier-transformed infrared spectroscopy and circular dichroism spectroscopy. The conformations of the beta 25-35 and beta 35-25 in solid state were identical and contained mostly beta-sheet structures. In solid state the amidated beta (25… CONTINUE READING

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