Conformations of proteins in equilibrium.

@article{Micheletti2001ConformationsOP,
  title={Conformations of proteins in equilibrium.},
  author={Cristian Micheletti and Jayanth R. Banavar and Amos Maritan},
  journal={Physical review letters},
  year={2001},
  volume={87 8},
  pages={
          088102
        }
}
We introduce a simple theoretical approach for an equilibrium study of proteins with known native-state structures. We test our approach with results on well-studied globular proteins, chymotrypsin inhibitor (2ci2), barnase, and the alpha spectrin SH3 domain, and present evidence for a hierarchical onset of order on lowering the temperature with significant organization at the local level even at high temperatures. A further application to the folding process of HIV-1 protease shows that the… CONTINUE READING

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