Conformations of immunoglobulin hypervariable regions

@article{Chothia1989ConformationsOI,
  title={Conformations of immunoglobulin hypervariable regions},
  author={Cyrus Chothia and Arthur M. Lesk and Anna Tramontano and Michael Levitt and S J Smith-gill and Gillian M. Air and Steven Sheriff and Eduardo A. Padlan and D. J. M. Davies and William R. Tulip and Peter M. Colman and Silvia Spinelli and Pedro M Alzari and Roberto J. Poljak},
  journal={Nature},
  year={1989},
  volume={342},
  pages={877-883}
}
On the basis of comparative studies of known antibody structures and sequences it has been argued that there is a small repertoire of main-chain conformations for at least five of the six hypervariable regions of antibodies, and that the particular conformation adopted is determined by a few key conserved residues. These hypotheses are now supported by reasonably successful predictions of the structures of most hypervariable regions of various antibodies, as revealed by comparison with their… CONTINUE READING
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