Conformations and dynamics of the phosphodiester backbone of a DNA fragment that bears a strong topoisomerase II cleavage site.

@article{Ren2007ConformationsAD,
  title={Conformations and dynamics of the phosphodiester backbone of a DNA fragment that bears a strong topoisomerase II cleavage site.},
  author={Brigitte Ren{\'e} and Gr{\'e}goire Masliah and Sa{\"i}d El Antri and Serge Fermandjian and Olivier Mauffret},
  journal={The journal of physical chemistry. B},
  year={2007},
  volume={111 16},
  pages={4235-43}
}
The dynamics of the DNA phosphodiester backbone conformations have been studied for a strong topoisomerase II cleavage site (site 22) using molecular dynamics simulations in explicit water and in the presence of sodium ions. We investigated the backbone motions and more particularly the BI/BII transitions involving the epsilon and zeta angles. The consensus… CONTINUE READING