Conformationally restrained aromatic analogues of fosmidomycin and FR900098.


The synthesis and in-vitro antimalarial activity of conformationally restrained bis(pivaloyloxymethyl) ester analogues of the natural product fosmidomycin is presented. In contrast to alpha-aryl-substituted analogues, conformationally restrained aromatic analogues exhibit only moderate in-vitro antimalarial activity against the chloroquine-sensitive strain… (More)


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@article{Kurz2007ConformationallyRA, title={Conformationally restrained aromatic analogues of fosmidomycin and FR900098.}, author={Thomas Kurz and Katrin Schl{\"{u}ter and M Katharina Pein and Christoph T Behrendt and B{\"a}rbel Bergmann and Rolf Walter}, journal={Archiv der Pharmazie}, year={2007}, volume={340 7}, pages={339-44} }