Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics.

@article{MartnMartnez2005ConformationallyCC,
  title={Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics.},
  author={M. Mart{\'i}n-Mart{\'i}nez and N. de la Figuera and M. Latorre and M. Garc{\'i}a-L{\'o}pez and E. Cenarruzabeitia and J. del R{\'i}o and R. Gonz{\'a}lez-Mu{\~n}iz},
  journal={Journal of medicinal chemistry},
  year={2005},
  volume={48 24},
  pages={
          7667-74
        }
}
To test whether a turnlike arrangement is involved in the bioactive conformation of CCK4 analogues upon CCK1 receptor recognition, we describe the preparation of two series of CCK4 derivatives, in which the central dipeptide Met-Asp has been replaced by recognized beta-turn mimetics {(2S,5S,11bR)- and (2R,5R,11bS)-2-amino-5-carboxy-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole (IBTM) and beta-turn dipeptide, 2-oxo-7-thio-1-azabicyclo[4.3.0]nonane (BTD)}. The incorporation of the… Expand
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