Conformationally Constrained Analogues of Diacylglycerol (DAG). 31. Modulation of the Biological Properties of Diacylgycerol Lactones (DAG-lactones) Containing Rigid-Rod Acyl Groups Separated from the Core Lactone by Spacer Units of Different Lengths

@inproceedings{Comin2009ConformationallyCA,
  title={Conformationally Constrained Analogues of Diacylglycerol (DAG). 31. Modulation of the Biological Properties of Diacylgycerol Lactones (DAG-lactones) Containing Rigid-Rod Acyl Groups Separated from the Core Lactone by Spacer Units of Different Lengths},
  author={Mar{\'i}a Julieta Comin and Gabriella Czifra and Noemi Kedei and Andrea Telek and Nancy E. Lewin and Sofiya Kolusheva and Julia F. Velasquez and Ryan Kobylarz and Raz Jelinek and Peter M. Blumberg and Victor E. Marquez},
  booktitle={Journal of medicinal chemistry},
  year={2009}
}
Diacylglycerol lactones built with a rigid 4-[(methylphenyl)ethynyl]phenyl rod that is separated from the exocyclic acylcarbonyl of the DAG-lactone core by a spacer unit of variable length were synthesized and studied. Binding affinities for a panel of classical and novel PKC isozymes in two different phospholipid environments, one corresponding to the plasma membrane of cells, were determined. The kinetics and site of translocation for the PKC isozymes alpha and delta upon treatment with the… CONTINUE READING

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