Conformational variability of nucleo-cytoplasmic transport factors.

  title={Conformational variability of nucleo-cytoplasmic transport factors.},
  author={Noemi Fukuhara and Elena Blanco Fern{\'a}ndez and Judith Ebert and Elena Conti and Dmitri Svergun},
  journal={The Journal of biological chemistry},
  volume={279 3},
The transport of macromolecules between the nucleus and cytoplasm of eukaryotic cells is largely mediated by a single family of transport factors, the karyopherin or importin beta-like family. Structural and biochemical evidence suggests conformational flexibility of these modular HEAT-repeat proteins is crucial for their regulation. Here we use small angle x-ray scattering to assess the extent of conformational variation within a set of nuclear import and export factors. The study reveals that… CONTINUE READING