Conformational transitions of adenylate kinase: switching by cracking.

  title={Conformational transitions of adenylate kinase: switching by cracking.},
  author={Paul C. Whitford and Osamu Miyashita and Yaakov Levy and Jos{\'e} N. Onuchic},
  journal={Journal of molecular biology},
  volume={366 5},
Conformational heterogeneity in proteins is known to often be the key to their function. We present a coarse grained model to explore the interplay between protein structure, folding and function which is applicable to allosteric or non-allosteric proteins. We employ the model to study the detailed mechanism of the reversible conformational transition of Adenylate Kinase (AKE) between the open to the closed conformation, a reaction that is crucial to the protein's catalytic function. We… CONTINUE READING

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