Conformational study reveals amino acid residues essential for hemagglutinating and anti-proliferative activities of Clematis montana lectin.

@article{Lu2014ConformationalSR,
  title={Conformational study reveals amino acid residues essential for hemagglutinating and anti-proliferative activities of Clematis montana lectin.},
  author={Bangmin Lu and Bin Zhang and Wei Qi and Yanan Zhu and Yan Zhao and Nan Zhou and Rong Sun and Jinku Bao and Chuanfang Wu},
  journal={Acta biochimica et biophysica Sinica},
  year={2014},
  volume={46 11},
  pages={
          923-34
        }
}
Clematis montana lectin (CML), a novel mannose-binding lectin purified from C. montana Buch.-Ham stem (Ranunculaceae), has been proved to have hemagglutinating activity in rabbit erythrocytes and apoptosis-inducing activity in tumor cells. However, the biochemical properties of CML have not revealed and its structural information still needs to be elucidated. In this study, it was found that CML possessed quite good thermostability and alkaline resistance, and its hemagglutinating activity was… CONTINUE READING

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