Conformational study of N-methylated alanine peptides and design of Abeta inhibitor.

@article{Nandel2014ConformationalSO,
  title={Conformational study of N-methylated alanine peptides and design of Abeta inhibitor.},
  author={Fateh Singh Nandel and Radhika Rani Jaswal},
  journal={Indian journal of biochemistry & biophysics},
  year={2014},
  volume={51 1},
  pages={7-18}
}
N-Methylation increases the proteolytic stability of peptides and leads to improved pharmacological and increased nematicidal property against plant pathogens. In this study, the quantum mechanical and molecular dynamic simulation approaches were used to investigate conformational behavior of peptides containing only N-methylated alanine (NMeAla) residues and N-methylated alanine and alanine residues at alternate positions. The amide bond geometry was found to be trans and the poly NMeAla… CONTINUE READING