Conformational studies by molecular mechanics and molecular orbital methods on the antiamoebic drug 1-(4-imidazolylsulfonyl)-4-phenylimidazole

Abstract

Abatract-Confonnational attributes of the antiamoebic drug I-(4imidazolylsulfonyl)-4-phenylimidazofe have been studied by molecular mechanics and M.O. methods. It is found that an electronic transition is possible from the HOMO to the LUMO, thus making the SO2 functional group more available for an electrophylic attack. No definite indication is found that… (More)
DOI: 10.1016/0097-8485(89)80003-8

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