Conformational stabilization of rat s-adenosylmethionine decarboxylase by putrescine.

@article{Wada2010ConformationalSO,
  title={Conformational stabilization of rat s-adenosylmethionine decarboxylase by putrescine.},
  author={Makiko Wada and Akira Shirahata},
  journal={Biological & pharmaceutical bulletin},
  year={2010},
  volume={33 11},
  pages={1800-5}
}
The activity and processing of mammalian S-adenosylmethionine decarboxylase (AdoMetDC) is stimulated by putrescine. To obtain new insights into the mechanism through which putrescine stimulates AdoMetDC, we investigated conformational changes in rat prostate AdoMetDC in the presence or absence of putrescine. We examined the reactivity of purified rat prostate AdoMetDC to the SH-reagent iodoacetic acid (IAA) and its susceptibility to proteolysis in the presence or absence of putrescine using… CONTINUE READING