Conformational stability and catalytic activity of PTEN variants linked to cancers and autism spectrum disorders.

@article{Johnston2015ConformationalSA,
  title={Conformational stability and catalytic activity of PTEN variants linked to cancers and autism spectrum disorders.},
  author={Sean B. Johnston and Ronald T. Raines},
  journal={Biochemistry},
  year={2015},
  volume={54 7},
  pages={1576-82}
}
Phosphoinositides are membrane components that play critical regulatory roles in mammalian cells. The enzyme PTEN, which catalyzes the dephosphorylation of the phosphoinositide PIP3, is damaged in most sporadic tumors. Mutations in the PTEN gene have also been linked to autism spectrum disorders and other forms of delayed development. Here, human PTEN is shown to be on the cusp of unfolding under physiological conditions. Variants of human PTEN linked to somatic cancers and disorders on the… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Similar Papers

Loading similar papers…