Conformational selection or induced fit? 50 years of debate resolved

Abstract

Exactly 50 years ago, biochemists raised the question of the mechanism of the conformational change that mediates "allosteric" interactions between regulatory sites and biologically active sites in regulatory/receptor proteins. Do the different conformations involved already exist spontaneously in the absence of the regulatory ligands (Monod-Wyman-Changeux… (More)
DOI: 10.3410/B3-19

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Cite this paper

@inproceedings{Changeux2011ConformationalSO, title={Conformational selection or induced fit? 50 years of debate resolved}, author={Jean-Pierre Changeux and Stuart J. Edelstein}, booktitle={F1000 biology reports}, year={2011} }