• Corpus ID: 18850205

Conformational selection and induced changes along the catalytic cycle of E. coli DHFR

  title={Conformational selection and induced changes along the catalytic cycle of E. coli DHFR},
  author={Thomas R. Weikl and David D. Boehr},
  journal={arXiv: Biomolecules},
Protein function often involves changes between different conformations. Central questions are how these conformational changes are coupled to the binding or catalytic processes during which they occur, and how they affect the catalytic rates of enzymes. An important model system is the enzyme dihydrofolate reductase (DHFR) from E. coli, which exhibits characteristic conformational changes of the active-site loop during the catalytic step and during unbinding of the product. In this article, we… 

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