Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase.

  title={Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase.},
  author={Colin J Jackson and J-L Foo and Nobuhiko Tokuriki and Livnat Afriat and Paul Carr and H Kim and Gottfried Schenk and Dan S. Tawfik and David L. Ollis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 51},
To efficiently catalyze a chemical reaction, enzymes are required to maintain fast rates for formation of the Michaelis complex, the chemical reaction and product release. These distinct demands could be satisfied via fluctuation between different conformational substates (CSs) with unique configurations and catalytic properties. However, there is debate as to how these rapid conformational changes, or dynamics, exactly affect catalysis. As a model system, we have studied bacterial… CONTINUE READING

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