Conformational properties of melatonin and two conformationally restricted agonists: a molecular mechanics and NMR spectroscopic study.

@article{Jansen1993ConformationalPO,
  title={Conformational properties of melatonin and two conformationally restricted agonists: a molecular mechanics and NMR spectroscopic study.},
  author={Johanna M. Jansen and Anders Karl{\'e}n and Cor J. Grol and Uli Hacksell},
  journal={Drug design and discovery},
  year={1993},
  volume={10 2},
  pages={115-33}
}
The hormone melatonin (N-acetyl-5-methoxytryptamine) has been implicated in the regulation of several neural and endocrine processes that are cued by the daily change in photoperiod. The conformational properties of melatonin and two conformationally restricted agonists, 8-methoxy-2-acetamidotetralin and cis-1-methyl-8-methoxy-2-acetamidotetralin, were examined as a starting point for SAR studies. The conformational analysis was carried out by means of molecular mechanics calculations (MM2-85… CONTINUE READING