Conformational properties of alpha-synuclein in its free and lipid-associated states.

  title={Conformational properties of alpha-synuclein in its free and lipid-associated states.},
  author={David Eliezer and Esin Kutluay and Robert H. Bussell and Greg H. Browne},
  journal={Journal of molecular biology},
  volume={307 4},
alpha-Synuclein (alphaS) is a presynaptic terminal protein that is believed to play an important role in the pathogenesis of Parkinson's disease (PD). We have used NMR spectroscopy to characterize the conformational properties of alphaS in solution as a free monomer and when bound to lipid vesicles and lipid-mimetic detergent micelles. Free wild-type alphaS is largely unfolded in solution, but exhibits a region with a preference for helical conformations that may be important in the aggregation… CONTINUE READING
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