Conformational polymorphic changes in the crystal structure of the chiral antiparasitic drug praziquantel and interactions with calcium carbonate

@article{BorregoSnchez2018ConformationalPC,
  title={Conformational polymorphic changes in the crystal structure of the chiral antiparasitic drug praziquantel and interactions with calcium carbonate},
  author={A. Borrego-S{\'a}nchez and E. Carazo and B. Albertini and N. Passerini and B. Perissutti and P. Cerezo and C. Viseras and A. Hern{\'a}ndez-Laguna and C. Aguzzi and I. S{\'a}inz-D{\'i}az},
  journal={European Journal of Pharmaceutics and Biopharmaceutics},
  year={2018},
  volume={132},
  pages={180–191}
}
Graphical abstract Figure. No Caption available. Abstract Praziquantel is an antiparasitic drug used for decades. Currently, the praziquantel commercial preparation is a racemic mixture, in which only the levo‐enantiomer possesses anthelmintic activity. The knowledge of its properties in the solid state and other chemical‐physical properties is necessary for improving its efficacy and applications. Drug solid dispersions were prepared with calcium carbonate at 1:5 drug to excipient weight ratio… Expand
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References

SHOWING 1-10 OF 45 REFERENCES
Molecular and crystal structure of praziquantel. Spectroscopic properties and crystal polymorphism.
  • 22
Structural characterization and enantioseparation of the chiral compound praziquantel.
  • 39
  • Highly Influential
Solubility properties of racemic praziquantel and its enantiomers.
  • 23
Molecular modeling and infrared and Raman spectroscopy of the crystal structure of the chiral antiparasitic drug Praziquantel
  • 14
A new soluble and bioactive polymorph of praziquantel
  • Debora Zanolla, B. Perissutti, +9 authors B. Albertini
  • Materials Science, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2018
  • 16
Preparation, Dissolution and Characterization of Praziquantel Solid Dispersions
  • 48
In vitro characterization of some biopharmaceutical properties of praziquantel.
  • 20
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