• DOI:10.1016/j.ejpb.2018.09.028
Corpus ID: 52894513

Conformational polymorphic changes in the crystal structure of the chiral antiparasitic drug praziquantel and interactions with calcium carbonate

@article{BorregoSnchez2018ConformationalPC,
  title={Conformational polymorphic changes in the crystal structure of the chiral antiparasitic drug praziquantel and interactions with calcium carbonate},
  author={A. Borrego-S{\'a}nchez and E. Carazo and B. Albertini and N. Passerini and B. Perissutti and P. Cerezo and C. Viseras and A. Hern{\'a}ndez-Laguna and C. Aguzzi and I. S{\'a}inz-D{\'i}az},
  journal={European Journal of Pharmaceutics and Biopharmaceutics},
  year={2018},
  volume={132},
  pages={180–191}
}

A. Borrego-Sánchez, E. Carazo, +7 authors I. Sáinz-Díaz

Published 2018

Chemistry, Medicine

European Journal of Pharmaceutics and Biopharmaceutics

Graphical abstract Figure. No Caption available. Abstract Praziquantel is an antiparasitic drug used for decades. Currently, the praziquantel commercial preparation is a racemic mixture, in which only the levo‐enantiomer possesses anthelmintic activity. The knowledge of its properties in the solid state and other chemical‐physical properties is necessary for improving its efficacy and applications. Drug solid dispersions were prepared with calcium carbonate at 1:5 drug to excipient weight ratio… CONTINUE READING

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