Conformational plasticity of RepB, the replication initiator protein of promiscuous streptococcal plasmid pMV158

@inproceedings{Boer2016ConformationalPO,
  title={Conformational plasticity of RepB, the replication initiator protein of promiscuous streptococcal plasmid pMV158},
  author={D. Roeland Boer and Jos{\'e} Angel Ruiz-Mas{\'o} and Manuel Rueda and Maxim V. Petoukhov and Cristina Mach{\'o}n and Dmitri I. Svergun and Modesto Orozco and Gloria del Solar and M. Dolores Coll},
  booktitle={Scientific reports},
  year={2016}
}
DNA replication initiation is a vital and tightly regulated step in all replicons and requires an initiator factor that specifically recognizes the DNA replication origin and starts replication. RepB from the promiscuous streptococcal plasmid pMV158 is a hexameric ring protein evolutionary related to viral initiators. Here we explore the conformational… CONTINUE READING