Conformational maturation and post-ER multisubunit assembly of gap junction proteins.

@article{Vanslyke2009ConformationalMA,
  title={Conformational maturation and post-ER multisubunit assembly of gap junction proteins.},
  author={Judy K Vanslyke and Christian C. Naus and Linda S. Musil},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 9},
  pages={
          2451-63
        }
}
For all previously well-characterized oligomeric integral membrane proteins, folding, multisubunit assembly, and recognition of conformationally immature molecules for degradation occurs at their organelle of synthesis. This cannot, however, be the case for the gap junction-forming protein connexin43 (Cx43), which when endogenously expressed undergoes multisubunit assembly into connexons only after its transport to the trans-Golgi network. We have developed two novel assays to assess Cx43… CONTINUE READING
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