Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method.

Abstract

Chromatin remodeling complexes (remodelers) are large, multisubunit macromolecular assemblies that use ATP hydrolysis to alter the structure and positioning of nucleosomes. The mechanisms proposed for remodeler action on nucleosomes are diverse, and require structural evaluation and insights. Previous reconstructions of remodelers using electron microscopy… (More)

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@article{Leschziner2007ConformationalFI, title={Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method.}, author={A. Leschziner and Anjanabha Saha and Jacqueline Wittmeyer and Yongli Zhang and C. Bustamante and Bradley R. Cairns and Eva Nogales}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2007}, volume={104 12}, pages={4913-8} }