Conformational evaluation of HIV-1 trimeric envelope glycoproteins using a cell-based ELISA assay.

Abstract

HIV-1 envelope glycoproteins (Env) mediate viral entry into target cells and are essential to the infectious cycle. Understanding how those glycoproteins are able to fuel the fusion process through their conformational changes could lead to the design of better, more effective immunogens for vaccine strategies. Here we describe a cell-based ELISA assay that… (More)
DOI: 10.3791/51995

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