Conformational epitopes detected by cross-reactive antibodies to envelope 2 glycoprotein of the hepatitis C virus.

@article{Nakano1999ConformationalED,
  title={Conformational epitopes detected by cross-reactive antibodies to envelope 2 glycoprotein of the hepatitis C virus.},
  author={Isao Nakano and Yoshihide Fukuda and Yoshiaki Katano and Tetsuo Hayakawa},
  journal={The Journal of infectious diseases},
  year={1999},
  volume={180 4},
  pages={1328-33}
}
The prevalence of anti-E2 antibody in persons chronically infected with hepatitis C virus (HCV) is high irrespective of viral genotype, and this cross-reactive antibody is thought to react with a conformational epitope. To investigate the characteristics of this anti-E2 antibody, the immunoreactivity of sera from HCV-1b-infected patients was measured against various modified forms of E2 glycoprotein derived from HCV-H (genotype 1a) by an immunofluorescence technique. Twelve of 18 patients were… CONTINUE READING

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