Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

  title={Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions},
  author={James B. Munro and Jason Gorman and Xiaochu Ma and Zhou Zhou and James Arthos and Dennis R. Burton and Wayne Chester Koff and Joel R. Courter and Amos B. Smith and Peter D. Kwong and Scott C. Blanchard and Walther Mothes},
The HIV-1 envelope (Env) mediates viral entry into host cells. To enable the direct imaging of conformational dynamics within Env, we introduced fluorophores into variable regions of the glycoprotein gp120 subunit and measured single-molecule fluorescence resonance energy transfer within the context of native trimers on the surface of HIV-1 virions. Our observations revealed unliganded HIV-1 Env to be intrinsically dynamic, transitioning between three distinct prefusion conformations, whose… CONTINUE READING
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