Conformational differences in the 3-D nanostructure of the immunoglobulin heavy-chain locus, a hotspot of chromosomal translocations in B lymphocytes.

@article{Esa2001ConformationalDI,
  title={Conformational differences in the 3-D nanostructure of the immunoglobulin heavy-chain locus, a hotspot of chromosomal translocations in B lymphocytes.},
  author={Arif Esa and Allen E Coleman and Prof. Edelmann and Santiago Silva and Christoph Cremer and Siegfried Janz},
  journal={Cancer genetics and cytogenetics},
  year={2001},
  volume={127 2},
  pages={168-73}
}
Spectral precision distance microscopy was utilized to detect small but nonetheless consistently present conformational differences between the immunoglobulin heavy-chain gene clusters (IgH) that reside on the two chromosome 12 homologues in all diploid cells of the mouse. The euclidian distance (i.e., the mean arithmetic three-dimensional [3-D] distance) between the 5' most IgH gene, C mu, and the 3' most IgH gene, C alpha, was used as the indicator to define the co-presence of a condensed IgH… CONTINUE READING