Conformational changes opening and closing the CFTR chloride channel: insights from cysteine scanning mutagenesis.


Cystic fibrosis, the most common lethal genetic disease affecting young people in North America, is caused by failure of the chloride ion channel known as CFTR (cystic fibrosis transmembrane conductance regulator). CFTR belongs to the large family of ATP-binding cassette (ABC) membrane transporters. In CFTR, ATP-driven events at the nucleotide-binding… (More)
DOI: 10.1139/bcb-2014-0038


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