Conformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH.

@article{Sneck2012ConformationalCO,
  title={Conformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH.},
  author={Mia Sneck and Su Duy Nguyen and Tero Pihlajamaa and Gebrenegus Yohannes and Marja-Liisa Riekkola and Ross Milne and Petri T. Kovanen and Katariina O{\"o}rni},
  journal={Journal of lipid research},
  year={2012},
  volume={53 9},
  pages={1832-9}
}
During atherogenesis, the extracellular pH of atherosclerotic lesions decreases. Here, we examined the effect of low, but physiologically plausible pH on aggregation of modified LDL, one of the key processes in atherogenesis. LDL was treated with SMase, and aggregation of the SMase-treated LDL was followed at pH 5.5-7.5. The lower the pH, the more extensive was the aggregation of identically prelipolyzed LDL particles. At pH 5.5-6.0, the aggregates were much larger (size >1 µm) than those… CONTINUE READING

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