Conformational changes of G protein-coupled receptors during their activation by agonist binding.

@article{Bissantz2003ConformationalCO,
  title={Conformational changes of G protein-coupled receptors during their activation by agonist binding.},
  author={Caterina Bissantz},
  journal={Journal of receptor and signal transduction research},
  year={2003},
  volume={23 2-3},
  pages={
          123-53
        }
}
The superfamily of G protein-coupled receptors (GPCRs) is the largest and most diverse group of transmembrane proteins involved in signal transduction. Many of the over 1000 human GPCRs represent important pharmaceutical targets. However, despite high interest in this receptor family, no high-resolution structure of a human GPCR has been resolved yet. This is mainly due to difficulties in obtaining large quantities of pure and active protein. Until now, only a high-resolution x-ray structure of… CONTINUE READING
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