Conformational changes of Aβ (1-42) monomers in different solvents.

Abstract

Amyloid proteins are known to be the main cause of numerous degenerative and neurodegenerative diseases. In general, amyloids are misfolded from monomers and they tend to have β-strand formations. These misfolded monomers are then transformed into oligomers, fibrils, and plaques. It is important to understand the forming mechanism of amyloids in order to… (More)
DOI: 10.1016/j.jmgm.2016.02.003

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