Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability.

@article{Waseem2004ConformationalCI,
  title={Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability.},
  author={Ahmad Waseem and Uwe Karsten and Irene May Leigh and Patricia E. Purkis and Naushin H. Waseem and E. Birgitte Lane},
  journal={Biochemistry},
  year={2004},
  volume={43 5},
  pages={1283-95}
}
Keratin intermediate filaments are heteropolymers of type I and type II polypeptides that constitute the bulk of the epithelial cytoskeleton. We microinjected seven keratin monoclonal antibodies into human epithelial cells, and two of them, only A45-B/B3 and LP3K, caused the formation of keratin aggregates. The keratin filaments in human epithelial cells… CONTINUE READING