Conformational changes in the parathyroid hormone receptor associated with activation by agonist.

Abstract

Binding of hormones to their cognate G protein-coupled receptors (GPCRs) induces conformational shifts within the receptor based on evidence from a few hormone-receptor systems. Employing an engineered disulfide bond formation strategy and guided by a previously established model of the PTH-PTH receptor (PTHR)1 bimolecular complex, we set out to document… (More)
DOI: 10.1210/me.2007-0520

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