Conformational changes in receptor tyrosine kinase signaling: an ErbB garden of delights

@inproceedings{Carraway2009ConformationalCI,
  title={Conformational changes in receptor tyrosine kinase signaling: an ErbB garden of delights},
  author={Kermit L. Carraway and Goldi A Kozloski},
  booktitle={F1000 biology reports},
  year={2009}
}
The ErbB family of receptor tyrosine kinases plays important roles in cell proliferation, differentiation, and apoptosis. Recent structural studies of these receptors have demonstrated dramatic conformational effects that are critical to their ligand binding and activation, and have shown that these receptors provide levels of control beyond the classic dimerization/activation mechanism. These results indicate that this class of receptors has evolved subtle regulatory mechanisms via genetic and… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 22 REFERENCES

Ligand-induced ErbB receptor dimerization.

  • Experimental cell research
  • 2009
VIEW 1 EXCERPT

Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2008
VIEW 1 EXCERPT

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