Conformational changes in quadruplex oligonucleotide structures probed by Raman spectroscopy

  title={Conformational changes in quadruplex oligonucleotide structures probed by Raman spectroscopy},
  author={Cynthia V. Pagba and Stephen M. Lane and Sebastian Wachsmann-Hogiu},
  booktitle={Biomedical optics express},
Quadruplex structures are higher order structures formed by guanine-rich oligonucleotides. In the present study, temperature-induced conformational changes in the quadruplex structures of aptamers and other guanine-rich oligonucleotides are probed by Raman spectroscopy. In particular, dramatic changes in the fingerprint region are observed in the spectra of thrombin binding aptamer at higher temperatures. These changes are accompanied by a decrease in the intensity of the 1480 cm(-1) peak… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-7 of 7 extracted citations


Publications referenced by this paper.
Showing 1-10 of 23 references

Raman and surfaceenhanced Raman spectroscopic studies of the 15mer DNA thrombinbinding aptamer

G. J. Thomas
J . Raman Spectrosc . • 2010

Tetramolecular Gquadruplex formation pathways studied by electrospray mass spectrometry

E. De Pauw
Nucleic Acids Res . • 2010

Validation of the drop coating deposition Raman method for protein analysis

N. J. Halas
Anal . Biochem . • 2006

Raman detection of proteomic analytes

A. E. Ribbe
Anal . Chem . • 2003

Similar Papers

Loading similar papers…