Conformational changes in quadruplex oligonucleotide structures probed by Raman spectroscopy

@inproceedings{Pagba2010ConformationalCI,
  title={Conformational changes in quadruplex oligonucleotide structures probed by Raman spectroscopy},
  author={Cynthia V. Pagba and Stephen M. Lane and Sebastian Wachsmann-Hogiu},
  booktitle={Biomedical optics express},
  year={2010}
}
Quadruplex structures are higher order structures formed by guanine-rich oligonucleotides. In the present study, temperature-induced conformational changes in the quadruplex structures of aptamers and other guanine-rich oligonucleotides are probed by Raman spectroscopy. In particular, dramatic changes in the fingerprint region are observed in the spectra of thrombin binding aptamer at higher temperatures. These changes are accompanied by a decrease in the intensity of the 1480 cm(-1) peak… CONTINUE READING

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