Conformational changes in p53 analysed using new antibodies to the core DNA binding domain of the protein.

@article{Vojtesek1995ConformationalCI,
  title={Conformational changes in p53 analysed using new antibodies to the core DNA binding domain of the protein.},
  author={Borivoj Vojtesek and Helena Dole{\vz}alov{\'a} and Ludmila Lauerov{\'a} and Miluska Svit{\'a}kov{\'a} and P. Havlis and Jan Kovař{\'i}k and Carol A Midgley and David Philip Lane},
  journal={Oncogene},
  year={1995},
  volume={10 2},
  pages={389-93}
}
The p53 protein contains a protease resistant core section that binds to DNA in a sequence specific manner and whose crystal structure has been determined. This core is flanked at the N-terminus by the transcriptional transactivation domain and at the C-terminus by sequences involved in the oligomerisation of the protein. Extensive immunochemical analysis of p53 has shown that dominant antigenic sites lie within these N- and C-terminal domains while few antibodies to the central core have been… CONTINUE READING

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