Conformational changes in extracellular loop 2 associated with signal transduction in the glycine receptor.

@article{Cederholm2010ConformationalCI,
  title={Conformational changes in extracellular loop 2 associated with signal transduction in the glycine receptor.},
  author={Jennie M. E. Cederholm and Nathan L. Absalom and Silas Sugiharto and Renate Griffith and Peter R. Schofield and Trevor M. Lewis},
  journal={Journal of neurochemistry},
  year={2010},
  volume={115 5},
  pages={1245-55}
}
Ligand-gated ion channels efficiently couple neurotransmitter binding to the opening of an intrinsic ion channel to generate the post-synaptic potentials that are characteristic of fast synaptic transmission. In the Cys-loop family of ligand-gated ion channels, the ligand-binding site is approximately 60 Å above the channel gate. Structural modelling of related proteins and mutagenesis studies led to the hypothesis that loops 2 and 7 of the extracellular domain may couple ligand binding to… CONTINUE READING