Conformational changes in calcium-sensor proteins under molecular crowding conditions.

@article{Sulmann2014ConformationalCI,
  title={Conformational changes in calcium-sensor proteins under molecular crowding conditions.},
  author={Stefan Sulmann and Daniele Dell'Orco and Valerio Marino and Petra Behnen and Karl-Wilhelm Koch},
  journal={Chemistry},
  year={2014},
  volume={20 22},
  pages={
          6756-62
        }
}
Fundamental components of signaling pathways are switch modes in key proteins that control start, duration, and ending of diverse signal transduction events. A large group of switch proteins are Ca(2+) sensors, which undergo conformational changes in response to oscillating intracellular Ca(2+) concentrations. Here we use dynamic light scattering and a recently developed approach based on surface plasmon resonance to compare the protein dynamics of a diverse set of prototypical Ca(2+)-binding… CONTINUE READING
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Neuronal Calcium Sensor Proteins, Nova Publishers, Hauppauge

  • P. P. Philippov, K.-W. Koch
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