Conformational changes associated with ion permeation in L-type calcium channels

  title={Conformational changes associated with ion permeation in L-type calcium channels},
  author={Daniela Pietrobon and Blaise Prod'hom and Peter Hess},
The mechanism by which ions deliver their message to effector proteins involves a change in the protein conformation which is induced by the specific interaction of the ion with its binding site on the protein. In the case of an ion-channel protein, conforma-tional changes induced by permeant ions and the consequences for channel function have received little attention. Here we report that binding of permeant cations to an intra-channel binding site of the dihydropyridine (DHP)-sensitive (L… CONTINUE READING

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