Conformational changes and truncation of tau protein during tangle evolution in Alzheimer's disease.

@article{GarcaSierra2003ConformationalCA,
  title={Conformational changes and truncation of tau protein during tangle evolution in Alzheimer's disease.},
  author={Francisco Garc{\'i}a-Sierra and Nupur Ghoshal and Bruce Quinn and Robert W. Berry and LesterI. Binder},
  journal={Journal of Alzheimer's disease : JAD},
  year={2003},
  volume={5 2},
  pages={
          65-77
        }
}
The conformation-dependent antibodies Tau-66 and Alz-50 recognize discontinuous epitopes on the tau molecule (residues 155-244 & 305-314 and 5-15 & 312-322, respectively), thereby defining two distinct conformations. In double- and triple-label immunofluorescence experiments we discovered that specific populations of neurofibrillary tangles display either the Alz-50 or the Tau-66 conformation, but not both. In combination with other antibodies to several domains of the molecule we demonstrate… CONTINUE READING

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